Since the prefix is part of both languages, it shouldn't be surprising that the prefix comes from Latin, specifically from the words male (badly) and malus (bad). The prefix can be parts of nouns, verb, adjectives and adverbs.
In most cases, you can easily guess what a mal- word means if you know the root word means. A few examples:
- malcomer, to eat poorly
- malentendido, misunderstanding
- malformación, malformation
- malhablado, foul-mouthed
- malherir, to injure badly
- malintencionado, with bad intentions
- malnutrición, malnutrition
- maloliente, bad-smelling
- malsano, unhealthy
- maltratar, to mistreat
- malvivir, to live poorly
- malasangre, evil-minded (from sangre, blood)
- malcriado, spoiled (said of a child, from criar, to raise a child)
- maldad, evil
- maldecir, to curse (from decir, to speak)
- maleado, corrupt
- maleducado, rude (from educar, to educate or to raise a child)
- malestar, uneasiness, unrest
- malgaster, to waste (from gastar, to spend)
- malhumor, bad mood, foul temper (from humor, mood or temperament)
- malicia, wickedness, malice
- malignidad, maligno, malignancy, malignant
- malograr, to waste
- malosante, rude
- malparado, in a bad state (from parar, to stop)
- maltraer, to mistreat
- maltrecho, battered
- malversar, to embezzle (from versar, to have dealings)

