The Spanish k is pronounced basically the same as it usually is in English, except perhaps a bit softer, often something like the "c" in "scatter."
The q is pronounced the same. As in English, the Spanish q is always followed by a u except in a very few words of foreign origin. Spanish is even more particular in the sequences in which the q is used: the qu is always followed by by an e or an i, and the u is silent. Thus que is pronounced something like "keh" would be in English and quien is pronounced something like "kyen."
The sound is also the same as the c sound except when the c precedes an e or i.
In order to maintain the correct pronunciation, the Spanish cognates of English words with "qua" or "quo" are often spelled with a c in Spanish instead. Thus the Spanish word for "quartz" is cuarzo, and the word for "quota" is cuota.
In the audio lesson on pronouncing the k and q you will hear the phrase "qué tal" and the number quince spoken by native speakers.